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Details Dapotin (DAPOXETINE) Medicine

DAPOXETINE in Bangladesh

AVAILABLE BRANDS IN BANGLADESH (BD)

PREJECT 30 (NIPRO JMI Pharma Limited)
DAPOREX(Euro Pharma Ltd.)
DUMAX 60(Eskayef Bangladesh Ltd., Tongi)
DUMAX 30(Eskayef Bangladesh Ltd., Tongi)
EJALONG 60(Drug International Ltd.)
EJALONG 30(Drug International Ltd.)
PLEZER 60(Delta Pharma Limited)
PLEZER 30(Delta Pharma Limited)
DAPOTIN(Beacon Pharmaceuticals Ltd.)
DULONG 30 MG (Radiant Pharmaceutical Ltd.)
DULONG 60 MG(Radiant Pharmaceutical Ltd.)
X-RIDE 30(Somatec Pharmaceuticals Ltd.)
X-RIDE 60(Somatec Pharmaceuticals Ltd.)
SUSTEN 30 (Square Pharmaceuticals Ltd. Pabna)
SUSTEN 60 (Square Pharmaceuticals Ltd. Pabna)
MATUREX 30(Incepta Pharmaceuticals Ltd.)
DURALAST 60(Sun Pharmaceutical (Bangladesh) Ltd.)
XTREME 30(Sharif Pharmaceuticals Ltd.)
XTREME 60(Sharif Pharmaceuticals Ltd.)
IMPREJA-30(Unimed & Unihealth Manufacturers Ltd.)
IMPREJA 60(Unimed & Unihealth Manufacturers Ltd.)
PROLONG 30(Ziska Pharmaceuticals Ltd.)
PROLONG 60(Ziska Pharmaceuticals Ltd.)
Details Dapotin (DAPOXETINE)

Details Dapotin (DAPOXETINE)

DAPOXETINE INDICATION

Indicated for the treatment of premature ejaculation (PE) in men 18 to 64 years of age, who have all of the following:

–  Persistent  or  recurrent  ejaculation  with  minimal  sexual  stimulation  before,  on  or shortly after penetration and before the patient wishes.

– Marked personal distress or interpersonal difficulty as a consequence of PE and poor control over ejaculation.

DAPOXETINE DOSAGE & ADMINISTRATION

Adult men (18 to 64 years of age): The recommended starting dose for all patients is 30 mg, taken as needed approximately 1 to 3 hours prior to sexual activity. If the effect of 30 mg is insufficient and the side effects are acceptable, the dose may be increased to the maximum recommended dose of 60 mg. The maximum recommended dosing frequency is one dose every 24 hours.

DAPOXETINE OVERDOSAGE

There  were  no  unexpected  adverse  events  in  a  clinical  pharmacology  study  of Dapoxetine  with  daily  doses  up  to  240  mg.  In  general,  symptoms  of  overdose  with SSRIs  include  serotonin-mediated  adverse  reactions  such  as  somnolence, gastrointestinal  disturbances  such  as  nausea  and  vomiting,  tachycardia,  tremor, agitation and dizziness. In cases of overdose, standard supportive measures should be adopted as required.

DAPOXETINE SIDE EFFECTS

Dizziness, Headache, Somnolence, Tremor, Blurred  vision, Tinnitus, Sinus congestion, Nausea, Diarrhea, Abdominal pain, Dry mouth, Fatigue, Insomnia, Hypertension.

DAPOXETINE CONTRAINDICATION

– Patients with known hypersensitivity to Dapoxetine Hydrochloride.

– Patients with significant pathological cardiac conditions such as heart failure (NYHA class  II-IV),  conduction  abnormalities  (second  or  third  degree  AV  block  or  sick  sinus syndrome)  not  treated  with  a  permanent  pacemaker,  significant  ischemic  heart disease of significant valvular disease.

–  Concomitant  treatment  with  monoamine  oxidase  inhibitors  (MAOIs),  thioridazine. Similarly,  MAOIs  or  thioridazine  should  not  be  administered  within  7  days  after Dapoxetine has been discontinued.

–  Concomitant  treatment  with  serotonin  reuptake  inhibitors  (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs) or  other  medicinal/herbal  products  with  serotonergic  effects  or  within  14  days  of discontinuing treatment with these medicinal/herbal products. 

DAPOXETINE DRUG INTERACTION

CNS active medicinal products: The use of Dapoxetine in combination with CNS active medicinal products has not been systematically evaluated in patients with premature ejaculation.  Consequently,  caution  is  advised  if  the  concomitant  administration  of Dapoxetine and such medicinal products is required.

PDE5 inhibitors: Tadalafil did not affect the pharmacokinetics of Dapoxetine. Sildenafil caused slight changes in Dapoxetine pharmacokinetics, which are not expected to be clinically  significant.  However,  Dapoxetine  should  be  prescribed  with  caution  in patients who use PDE5 inhibitors due to possible reduced orthostatic tolerance.

Tamsulosin: Concomitant administration of single or multiple doses of 30 mg or 60 mg Dapoxetine to patients receiving daily doses of Tamsulosin did not result in changes in the pharmacokinetics of Tamsulosin. However, Dapoxetine should be prescribed with caution  in  patients  who  use  alpha  adrenergic  receptor  antagonists  due  to  possible reduced orthostatic tolerance.

Warfarin:  There  are  no  data  evaluating  the  effect  of  chronic  use  of  Warfarin  with Dapoxetine; therefore, caution is advised when Dapoxetine is used in patients taking Warfarin chronically.

Ethanol:  Concomitant  use  of  alcohol  and  Dapoxetine  could  increase  the  chance  or the severity  of  adverse  reactions  such  as  dizziness,  drowsiness,  slow  reflexes,  or  altered judgment.  Combining  alcohol  with  Dapoxetine  may  increase  these  alcohol-related effects  and  may  also  enhance  neuro cardiogenic  adverse  events  such  as  syncope, thereby increasing the risk of accidental injury; therefore, patients should be advised to avoid alcohol while taking Dapoxetine.

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Afsana Spell

আমি আফসানা। Health Bangla ডট কম এর একজন লেখক। পেশায় MBBS Doctor। বর্তমানে Internship শেষ করে Training এ আছি। আমাকে আপনার সমস্যার কথা লিখে পাঠান afsanaspell@gmail.com ইমেইল এ।
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